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世界肝炎日:抗逆转录病毒药物也有利于丙肝的治疗

浏览数:1261 07月29日 来源:携手在线 作者:携手在线   | 
7月28日是世界肝炎日,这个节日旨在提高全世界对病毒性肝炎的认识。大约每五百万个艾滋病毒感染者中,有15%的人会交叉感染丙肝。它会影响到易感人群,这些人群同时也有很高的艾滋病毒感染风险,尤其是在非洲、亚洲和东欧地区。

7月28日是世界肝炎日,这个节日旨在提高全世界对病毒性肝炎的认识。目前有五种类型的肝炎病毒,分别被称为甲肝、乙肝、丙肝、丁肝和戊肝。丙肝被认为导致了艾滋病毒的双重流行,因为它在艾滋病人群中非常普遍。大约每五百万个艾滋病毒感染者中,有15%的人会交叉感染丙肝。它会影响到易感人群,这些人群同时也有很高的艾滋病毒感染风险,尤其是在非洲、亚洲和东欧地区。

发达国家的丙肝和艾滋病治疗

今年两种最新丙肝药物的发布 - Sofosbuvir 和Simeprevir – 使发达国家最近12-24周内90%的治疗是成功的。这些新药也有助于艾滋病的治疗,这刚好与以前的肝炎治疗相反,以前的药物对艾滋病感染者的成功率较低。

发展中国家丙肝和艾滋病的治疗

丙肝完全可以被治愈,然而有效的丙肝治疗往往无法再中低收入国家之间展开,因为这些治疗的费用过高。丙肝会造成人体肝脏的破坏,由于免疫系统被破坏,艾滋病感染者病情恶化速度比其他人更快。如果丙肝不进行治疗,它会导致威胁生命的肝硬化。关于艾滋病和丙肝交叉感染者的主要担心是不确定在艾滋病治疗中使用抗逆转录药物会不会影响到这个人的肝脏以及导致丙肝的恶化。因此医生治疗丙肝患者的方法和治疗交叉感染患者的方法不一样。

幸运的是,一项发表在“科学转化医学”上的新的研究断定,治疗艾滋病的抗逆转录药物对丙型肝炎病毒有直接的影响。这项研究中17个交叉感染了艾滋病和丙肝的病人接受了抗逆转录药物治疗,结果发现丙型肝炎病毒在他们血液中的载量下降,表明抗逆转录病毒药物似乎阻止了病毒繁殖。解释是抗逆转录药物减少肝脏炎症和丙型肝炎病毒负荷。

虽然在中低收入国家中,无法使用到最有效的治疗丙肝的药物,早期艾滋病人和丙肝交叉感染患者的抗逆转录病毒疗法在治疗丙肝的过程中是很重要的。

原文标题《World Hepatitis Day: Antiretroviral drug also benefits the treatment of hepatitis C》

英文原文:

July 28th is World Hepatitis Day, which aims to raise awareness of viral hepatitis around the world. There are five main types of hepatitis virus, referred to as types A, B, C, D and E. Hepatitis C is considered to be causing a “dual epidemic” with HIV because it is highly prevalent in HIV-endemic areas. About five million people living with HIV, or 15% of the total, are co-infected with hepatitis C. It disproportionately affects vulnerable populations that also have a high risk of developing HIV infections, especially in Africa, Asia and Eastern Europe.

Hepatitis C and HIV treatment in developed countries

The release of two new hepatitis C drugs - Sofosbuvir and Simeprevir – this year has enabled 90 percent of treatments to be successful within 12 - 24 weeks in developed countries. These new drugs are also very effective at treating HIV, in contradiction to the old hepatitis treatment regimes that had low success rates in people living with HIV.

Treatment of hepatitis C and HIV in developing countries

Hepatitis C can be completely cured, although effective hepatitis C treatments are often inaccessible in low- and middle-income countries due to the high costs of these treatments. Hepatitis C, which causes a destruction of the liver, progresses faster in people living with HIV than other people, caused by their weakened immune systems. If hepatitis C is untreated it could result in a life threatening liver cirrhosis. The main worry regarding HIV and Hepatitis C co-infections is the uncertainty that the antiretroviral drugs used in HIV treatments may affect a person's liver and worsen a hepatitis C infection. Doctors therefore used to treat people living with a co-infection differently from those who only had hepatitis C.

Promisingly, a new study published in " Science Translational Medicine” concludes that antiretroviral drugs used in HIV treatment can have a direct effect on the hepatitis C virus. The study, including 17 patients co-infected with HIV and Hepatitis C receiving antiretroviral drug therapy, found that the hepatitis C viral load in their blood dropped, implying that the antiretroviral drug seemed to stop the virus from multiplying. The explanation is that antiretroviral drugs decrease liver inflammation and reduce the hepatitis C virus load.

Although the most effective hepatitis C drugs might not yet be available in low- and middle-income countries, early antiretroviral treatment of people living with HIV and hepatitis C co-infection is important in the fight against Hepatitis C.

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世界肝炎日:抗逆转录病毒药物也有利于丙肝的治疗

0 0 来源:携手在线 作者: 07月29日
7月28日是世界肝炎日,这个节日旨在提高全世界对病毒性肝炎的认识。大约每五百万个艾滋病毒感染者中,有15%的人会交叉感染丙肝。它会影响到易感人群,这些人群同时也有很高的艾滋病毒感染风险,尤其是在非洲、亚洲和东欧地区。

7月28日是世界肝炎日,这个节日旨在提高全世界对病毒性肝炎的认识。目前有五种类型的肝炎病毒,分别被称为甲肝、乙肝、丙肝、丁肝和戊肝。丙肝被认为导致了艾滋病毒的双重流行,因为它在艾滋病人群中非常普遍。大约每五百万个艾滋病毒感染者中,有15%的人会交叉感染丙肝。它会影响到易感人群,这些人群同时也有很高的艾滋病毒感染风险,尤其是在非洲、亚洲和东欧地区。

发达国家的丙肝和艾滋病治疗

今年两种最新丙肝药物的发布 - Sofosbuvir 和Simeprevir – 使发达国家最近12-24周内90%的治疗是成功的。这些新药也有助于艾滋病的治疗,这刚好与以前的肝炎治疗相反,以前的药物对艾滋病感染者的成功率较低。

发展中国家丙肝和艾滋病的治疗

丙肝完全可以被治愈,然而有效的丙肝治疗往往无法再中低收入国家之间展开,因为这些治疗的费用过高。丙肝会造成人体肝脏的破坏,由于免疫系统被破坏,艾滋病感染者病情恶化速度比其他人更快。如果丙肝不进行治疗,它会导致威胁生命的肝硬化。关于艾滋病和丙肝交叉感染者的主要担心是不确定在艾滋病治疗中使用抗逆转录药物会不会影响到这个人的肝脏以及导致丙肝的恶化。因此医生治疗丙肝患者的方法和治疗交叉感染患者的方法不一样。

幸运的是,一项发表在“科学转化医学”上的新的研究断定,治疗艾滋病的抗逆转录药物对丙型肝炎病毒有直接的影响。这项研究中17个交叉感染了艾滋病和丙肝的病人接受了抗逆转录药物治疗,结果发现丙型肝炎病毒在他们血液中的载量下降,表明抗逆转录病毒药物似乎阻止了病毒繁殖。解释是抗逆转录药物减少肝脏炎症和丙型肝炎病毒负荷。

虽然在中低收入国家中,无法使用到最有效的治疗丙肝的药物,早期艾滋病人和丙肝交叉感染患者的抗逆转录病毒疗法在治疗丙肝的过程中是很重要的。

原文标题《World Hepatitis Day: Antiretroviral drug also benefits the treatment of hepatitis C》

英文原文:

July 28th is World Hepatitis Day, which aims to raise awareness of viral hepatitis around the world. There are five main types of hepatitis virus, referred to as types A, B, C, D and E. Hepatitis C is considered to be causing a “dual epidemic” with HIV because it is highly prevalent in HIV-endemic areas. About five million people living with HIV, or 15% of the total, are co-infected with hepatitis C. It disproportionately affects vulnerable populations that also have a high risk of developing HIV infections, especially in Africa, Asia and Eastern Europe.

Hepatitis C and HIV treatment in developed countries

The release of two new hepatitis C drugs - Sofosbuvir and Simeprevir – this year has enabled 90 percent of treatments to be successful within 12 - 24 weeks in developed countries. These new drugs are also very effective at treating HIV, in contradiction to the old hepatitis treatment regimes that had low success rates in people living with HIV.

Treatment of hepatitis C and HIV in developing countries

Hepatitis C can be completely cured, although effective hepatitis C treatments are often inaccessible in low- and middle-income countries due to the high costs of these treatments. Hepatitis C, which causes a destruction of the liver, progresses faster in people living with HIV than other people, caused by their weakened immune systems. If hepatitis C is untreated it could result in a life threatening liver cirrhosis. The main worry regarding HIV and Hepatitis C co-infections is the uncertainty that the antiretroviral drugs used in HIV treatments may affect a person's liver and worsen a hepatitis C infection. Doctors therefore used to treat people living with a co-infection differently from those who only had hepatitis C.

Promisingly, a new study published in " Science Translational Medicine” concludes that antiretroviral drugs used in HIV treatment can have a direct effect on the hepatitis C virus. The study, including 17 patients co-infected with HIV and Hepatitis C receiving antiretroviral drug therapy, found that the hepatitis C viral load in their blood dropped, implying that the antiretroviral drug seemed to stop the virus from multiplying. The explanation is that antiretroviral drugs decrease liver inflammation and reduce the hepatitis C virus load.

Although the most effective hepatitis C drugs might not yet be available in low- and middle-income countries, early antiretroviral treatment of people living with HIV and hepatitis C co-infection is important in the fight against Hepatitis C.

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